Prelink might be helpful when building Wine. It's used to assign fixed addresses to a few built-in, system dlls (ntdll, kernel32, user) because some Windows programs assume that these DLLs will always be loaded at the same address. The Wine binary itself does not require prelink to be active; prelink is only used used to alter the mentioned DLLs at build-time.
- The wikipedia article on [en.wikipedia.org/wiki/Prelink prelink]
A mailing list thread that explains why prelink is used to build Wine